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help > RE: CONN denoising & Eklund clusterwise inflation
Jul 2, 2019 12:07 AM | Stephen L. - Coma Science Group, GIGA-Consciousness, Hospital & University of Liege
RE: CONN denoising & Eklund clusterwise inflation
Hello there, just a quick update given new development, it seems
that aCompCor might not only reduce the issue but fix it
altogether, this is what is suggested in the followup paper of
Eklund et al, Cluster Failure Revisited, where they tested ICA but
not PCA regression of noise but they expect a similar enhancement
to the false positive rate inflation :-)
* Eklund, A., Knutsson, H., & Nichols, T. E. (2019). Cluster failure revisited: Impact of first level design and physiological noise on cluster false positive rates. Human brain mapping, 40(7), 2017-2032.
Also another paper shown that modelling accurately the autocorrelation function greatly increases fMRI reliability, which suggests the fp inflation is mainly due to the autocorrelation function being either incorrectly modelled in some software packages and/or not enough regressed.
* Olszowy, W., Aston, J., Rua, C., & Williams, G. B. (2019). Accurate autocorrelation modeling substantially improves fMRI reliability. Nature communications, 10(1), 1220.
Best regards,
Stephen
* Eklund, A., Knutsson, H., & Nichols, T. E. (2019). Cluster failure revisited: Impact of first level design and physiological noise on cluster false positive rates. Human brain mapping, 40(7), 2017-2032.
Also another paper shown that modelling accurately the autocorrelation function greatly increases fMRI reliability, which suggests the fp inflation is mainly due to the autocorrelation function being either incorrectly modelled in some software packages and/or not enough regressed.
* Olszowy, W., Aston, J., Rua, C., & Williams, G. B. (2019). Accurate autocorrelation modeling substantially improves fMRI reliability. Nature communications, 10(1), 1220.
Best regards,
Stephen
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Title | Author | Date |
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Stephen L. | Nov 23, 2017 | |
Stephen L. | Jan 15, 2018 | |
Alfonso Nieto-Castanon | Nov 24, 2017 | |
Stephen L. | Nov 27, 2017 | |
Stephen L. | Jul 2, 2019 | |