Dear Andrew,

Thank you very much, the follow is the simply design:
1 0 0 0 25 0
0 1 0 0 21 0
0 0 1 0 33 0
1 0 0 1 90 90
0 1 0 1 83 83
0 0 1 1 96 96
the first 3 columns for each subject , the 4th column for timepoint, 5th column for language score,
6th column for interaction between language score and time.
if I want to study the correlation between the connectivity change and score change,
the contrast : [0 0 0 0 0 1]
and if I want to study the correlation between the connectivity and the language score,
the contrast :[0 0 0 0 1 0]
all this with ttest th=3.
exchange block [ 1 2 3 1 2 3] .
Is this design accurate? because I really confuse on to remove score' column, if I want to study the interaction, remove score' column, and just keep last column how it calculate the change of language score.
Best
Xuehu