Hi Chris,

Hope you are doing well.
I had the same issue when using the latest version: 1.2.20211006 on my mac big Sur 11.5.2.
"Unable to find Python home: /System/Library/Frameworks/Python.framework/Versions/Current/lib/libpython2.7.dylib/python37"

1. Can you provide the text when you choose MRIcroGL/About
1.2.20211006 Cocoa x86-64 LLVM
Author: Chris Rorden
License: BSD 2-Clause
Version 11.5.2 (Build 20G95) MacBookPro16,1
Retina Scale: 2
ATI Technologies Inc.; OpenGL= 2.1 ATI-4.6.20; Shader=1.20
2.1 Max 3D texture: 16384
Current texture: 207×256×215 43mb

2. Can you paste the output of running "sw_vers" from the terminal command line?
ProductName: macOS
ProductVersion: 11.5.2
BuildVersion: 20G95

One thing that may be related, when I type "which python" in terminal, i got
which python
/Users/u250167/opt/anaconda3/bin/python

Could you give me some advice on this? Thanks