help > RE: ANOVA 2x2 on longitudinal dataset
Nov 19, 2022  12:11 AM | Alfonso Nieto-Castanon - Boston University
RE: ANOVA 2x2 on longitudinal dataset
Hi Stefano,

You did not quite finish the description of your analysis, but assuming that:

a) after selecting 'AllSubjects', 'Treatment', and 'Age' in the 'subject effects' list, you then entered in the 'between-subjects contrast' field the vector [0 1 0] (to look at the effect of 'treatment')

and b) that in the 'conditions' list you had selected 'pre' and 'post', and entered a [-1 1] vector in the 'between-conditions contrast' field

then yes, that contrast would be evaluating the effect of the drug, i.e. the interaction between intervention (post vs. pre) and treatment (drug vs. placebo), while controlling for age (i.e. possible age-related post-pre differences in connectivity)

Originally posted by Stefano D:
Hi list, 
please could you check my design

I have baseline (no treatment for all groups) and post (treatment for all groups)
two groups of treatment: drug vs. placebo
two groups of subjects: young vs. elderly.

I would like to verify the effect of drug vs placebo, taking in account (age groups) and possible interaction.

I have done:

MRI/fMRI windows
all subjects in with two longitudinal sessions (session1: pre, session2: post) 

second covariates window:
- Subjects ---> 1 x N subjects  [1 1 1 1 1 1 1 1 1 1 1]
- Treatment --> 1 for drug, -1 for placebo, therefore [1 1 -1 1 -1 -1 -1 1 -1 1]
- Aging ---> 1 for young, -1 for elderly, therefore [1 1 1 1 1 -1 -1 -1 -1 -1]

For second level analysis, I have selected on left panel: Subjects, Treatment, Aging.

Is this procedure corrected?


Kind regards

Threaded View

Stefano D Nov 17, 2022
RE: ANOVA 2x2 on longitudinal dataset
Alfonso Nieto-Castanon Nov 19, 2022
Stefano D Nov 24, 2022