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help > RE: ANOVA 2x2 on longitudinal dataset
Nov 24, 2022 08:11 PM | Stefano D
RE: ANOVA 2x2 on longitudinal dataset
Thanks Alfonso for your prompt
response.
Yes, your assumption are corrected.
Anyway, I would also clarify that
# I have time point1 (no treatment for all groups) and time point2 (treatment for all groups)
two groups of treatment: drug vs. placebo
two groups of subjects: young vs. elderly.
I would like to verify the effect of drug vs placebo, taking in account (age groups) and possible interaction.
The effect of drug is therefore an acute effect at timepoint2.
# on point b) I have two blocks, one for each of the two session undergoing subjects. I have turn off the left block for time point1 (baseline) and the right block for time point2.
Stefano
Originally posted by Alfonso Nieto-Castanon:
Yes, your assumption are corrected.
Anyway, I would also clarify that
# I have time point1 (no treatment for all groups) and time point2 (treatment for all groups)
two groups of treatment: drug vs. placebo
two groups of subjects: young vs. elderly.
I would like to verify the effect of drug vs placebo, taking in account (age groups) and possible interaction.
The effect of drug is therefore an acute effect at timepoint2.
# on point b) I have two blocks, one for each of the two session undergoing subjects. I have turn off the left block for time point1 (baseline) and the right block for time point2.
Stefano
Originally posted by Alfonso Nieto-Castanon:
Hi
Stefano,
You did not quite finish the description of your analysis, but assuming that:
a) after selecting 'AllSubjects', 'Treatment', and 'Age' in the 'subject effects' list, you then entered in the 'between-subjects contrast' field the vector [0 1 0] (to look at the effect of 'treatment')
and b) that in the 'conditions' list you had selected 'pre' and 'post', and entered a [-1 1] vector in the 'between-conditions contrast' field
then yes, that contrast would be evaluating the effect of the drug, i.e. the interaction between intervention (post vs. pre) and treatment (drug vs. placebo), while controlling for age (i.e. possible age-related post-pre differences in connectivity)
Best
Alfonso
Originally posted by Stefano D:
You did not quite finish the description of your analysis, but assuming that:
a) after selecting 'AllSubjects', 'Treatment', and 'Age' in the 'subject effects' list, you then entered in the 'between-subjects contrast' field the vector [0 1 0] (to look at the effect of 'treatment')
and b) that in the 'conditions' list you had selected 'pre' and 'post', and entered a [-1 1] vector in the 'between-conditions contrast' field
then yes, that contrast would be evaluating the effect of the drug, i.e. the interaction between intervention (post vs. pre) and treatment (drug vs. placebo), while controlling for age (i.e. possible age-related post-pre differences in connectivity)
Best
Alfonso
Originally posted by Stefano D:
Hi list,
please could you check my design
I have baseline (no treatment for all groups) and post (treatment for all groups)
two groups of treatment: drug vs. placebo
two groups of subjects: young vs. elderly.
I would like to verify the effect of drug vs placebo, taking in account (age groups) and possible interaction.
I have done:
MRI/fMRI windows
all subjects in with two longitudinal sessions (session1: pre, session2: post)
second covariates window:
- Subjects ---> 1 x N subjects [1 1 1 1 1 1 1 1 1 1 1]
- Treatment --> 1 for drug, -1 for placebo, therefore [1 1 -1 1 -1 -1 -1 1 -1 1]
- Aging ---> 1 for young, -1 for elderly, therefore [1 1 1 1 1 -1 -1 -1 -1 -1]
For second level analysis, I have selected on left panel: Subjects, Treatment, Aging.
Is this procedure corrected?
Thanks
Kind regards
please could you check my design
I have baseline (no treatment for all groups) and post (treatment for all groups)
two groups of treatment: drug vs. placebo
two groups of subjects: young vs. elderly.
I would like to verify the effect of drug vs placebo, taking in account (age groups) and possible interaction.
I have done:
MRI/fMRI windows
all subjects in with two longitudinal sessions (session1: pre, session2: post)
second covariates window:
- Subjects ---> 1 x N subjects [1 1 1 1 1 1 1 1 1 1 1]
- Treatment --> 1 for drug, -1 for placebo, therefore [1 1 -1 1 -1 -1 -1 1 -1 1]
- Aging ---> 1 for young, -1 for elderly, therefore [1 1 1 1 1 -1 -1 -1 -1 -1]
For second level analysis, I have selected on left panel: Subjects, Treatment, Aging.
Is this procedure corrected?
Thanks
Kind regards
Threaded View
| Title | Author | Date |
|---|---|---|
| Stefano D | Nov 17, 2022 | |
| Alfonso Nieto-Castanon | Nov 19, 2022 | |
| Stefano D | Nov 24, 2022 | |