Freeware Yes Johns Hopkins University NITRC DOTS WM tract segmentation Yes Justin Senseney Diffusion-Oriented Tract Segmentation (DOTS) is a fast, scalable tool developed at the Johns Hopkins University to automatically segment the major anatomical fiber tracts within the human brain from clinical quality diffusion tensor MR imaging. With an atlas-based Markov Random Field representation, DOTS directly estimates the tract probabilities, bypassing tractography and associated issues. Overlapping and crossing fibers are modeled and DOTS can also handle white matter lesions. DOTS is released as a plug-in for the MIPAV software package and as a module for the JIST pipeline environment. They are therefore cross-platform and compatible with a wide variety of file formats. 2012-4-30 DOTS utilities for release 2A 2012-3-26 DOTS release 2a 2011-2-28 Release 1B 2011-1-28 DOTS Release 1A DOTS WM tract segmentation Apraxias, Bipolar Disorder, Autistic Disorder, Dyslexia, Child Development Disorders, Pervasive, Epilepsy, Attention Deficit Disorder with Hyperactivity, Stroke, Tourette Syndrome, Diabetes Mellitus, Huntington Disease, Tobacco Use Disorder, Aphasia, Ataxia, Brain Injuries, Schizophrenia, Multiple Sclerosis, Parkinson Disease, Neurofibromatosis 1, Depression, Obsessive-Compulsive Disorder, Amyotrophic Lateral Sclerosis, Muscular Dystrophies, Creutzfeldt-Jakob Syndrome, Alzheimer Disease, MR, Freeware http://www.nitrc.org/projects/dots/, http://www.nitrc.org/projects/dots/ SenseneyJ@mail.nih.gov