Computational Functional Anatomy Laboratory NUS Imaging Genetics, Free For Non-Commercial Use Only Yes National University of Singapore NITRC Mixed Effect Model of Genetic-Set and Environment Interaction OS Independent Yes MATLAB Toolbox: Mixed Effect Model of Genetic-Set and Environment Interaction for Neuroimage applications This MATLAB Toolbox provides a mixed effect model for gene-environment interaction (MixGE) on neuroimaging phenotypes, such as structural volumes and tensor-based morphometry (TBM). This model incorporates both fixed and random effects of genetic-set and environment interaction, to investigate homogeneous and heterogeneous contributions of sets of genetic variants and their interaction with environmental risks to phenotypes. To avoid direct parameter estimation in the MixGE model due to small sample size and high computational cost, score statistics were constructed for the terms associated with fixed and random effects of the genetic-set and environment interaction. They were combined into a single significance value. Mixed Effect Model of Genetic-Set and Environment Interaction Algorithm or Reusable Library, 5 - Production/Stable/Mature, Imaging Genomics, Clinical Neuroinformatics, Domain Independent, MR, End Users, NUS Imaging Genetics, Free For Non-Commercial Use Only, English, OS Independent, MATLAB, ANALYZE http://www.nitrc.org/projects/mixge/, http://http://http://www.bioeng.nus.edu.sg/cfa/imaginggenetics.html