Bio Imaging Signal Processing Laboratory GNU General Public License (GPL) Yes Korea Advanced Institute of Science and Technology (KAIST) NITRC NIRS-SPM Yes NIRS-SPM is a SPM and MATLAB-based software package for statistical analysis of near-infrared spectroscopy (NIRS) signals, developed at the Bio Imaging Signal Processing (BISP) lab. at KAIST in Korea. Based on the general linear model (GLM), and Sun's tube formula / Lipschitz-Killing curvature (LKC) based expected Euler characteristics, NIRS-SPM not only provides activation maps of oxy-, deoxy-, and total-hemoglobin, but also allows for super-resolution activation localization. Additional features, including a wavelet-minimum description length detrending algorithm and cerebral metabolic rate of oxygen (CMRO2) estimation without hypercapnia, were implemented in the NIRS-SPM software package. 2012-7-11 NIRS-SPM v4-r1 NIRS-SPM Optical Imaging, GNU General Public License (GPL), Epilepsy, Schizophrenia, Stroke, Dementia, Brain Concussion, Hydrocephalus, Brain Injuries,