Martinos Biomedical Imaging Center BSD License Yes Massachusetts General Hospital NITRC PICASSO skull stripping tool The Personalized Congregation of Algorithms for Skull Stripping Optimization (PICASSO) tool is a general skull stripping for T1-weighted brain MRIs (a) in multiple imaging sites; (b) by scanners of various vendors (GE/Siemens/Philips); (c) by scanners of various magnetic field strengths (1.0T/1.5T/3T/7T); (d) by various T1-weighted pulse sequences (MPRAGE, SPGR, etc); (e) with various fields-of-view (even containing neck and shoulders); (f) from subjects of various ages (infants, pediatrics, young adults, elderly adults); (g) from subjects of different health conditions (normative, dementia, tumor-bearing); (h) with various image resolutions (from 1x1x1mm to 1.5x1.5x6mm); and (i) with various image contrasts (high or low SNRs). The PICASSO tool runs in the unix command line. It is compatible with a single linux/mac computer, or preferably with high-performance parallel clusters (PBS or SGE). Publication pending. PICASSO skull stripping tool BSD License, MR http://www.nitrc.org/projects/picasso/, http://www.nitrc.org/projects/picasso/