Yes NITRC VectorValuedHistogramNormalizer Mark Scully Implement the methods defined in http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2006/Jaeger06-ANM.pdf as and ITK filter. VectorValuedHistogramNormalizer MR http://www.nitrc.org/projects/vvhistomatch/, http://www.nitrc.org/projects/vvhistomatch/ mark-scully@uiowa.edu