Wisconsin Alzheimer's Disease Research Center Academic Free License ("AFL") Yes University of Wisconsin - Madison NITRC Wisconsin White Matter Hyperintensities Segmentation Toolbox Yes MATLAB Nikhil Kannan W2MHS is an open source MATLAB toolbox designed for detecting and quantifying White Matter Hyperintensities(WMH) in Alzheimer’s and aging related neurological disorders.Our toolbox provides a self-sufficient set of tools for segmenting these WMHs reliably and further quantifying their burden for down-processing studies. WMHs arise as bright regions on T2-weighted FLAIR images. They reflect comorbid neural injury or cerebral vascular disease burden. Their precise detection is of interest in Alzheimer’s disease (AD) with regard to its prognosis. Please cite the following paper upon usage of this toolbox. Ithapu, V., Singh, V., Lindner, C., Austin, B. P., Hinrichs, C., Carlsson, C. M., Bendlin, B. B. and Johnson, S. C. (2014), Extracting and summarizing white matter hyperintensities using supervised segmentation methods in Alzheimer's disease risk and aging studies. Hum. Brain Mapp.. doi: 10.1002/hbm.22472 2016-4-03 W2MHS_v2.1_Linux 2016-4-03 W2MHS_v2.1_Windows 2014-4-02 W2MHS Sample Images 2013-11-09 W2MHS v1.3 [Windows] 2013-11-06 W2MHS v1.3 [Linux] 2013-5-28 W2MHS v1.1 [Linux] Source Only 2013-5-28 W2MHS v1.1 [Linux] Source and Training Data Wisconsin White Matter Hyperintensities Segmentation Toolbox Computational Neuroscience, Academic Free License ("AFL"), MATLAB, NIfTI-1, Migraine Disorders, Stroke, Multiple Sclerosis, Huntington Disease, Ataxia, Parkinson Disease, Alzheimer Disease, Amyotrophic Lateral Sclerosis http://www.nitrc.org/projects/w2mhs/, http://www.nitrc.org/projects/w2mhs/ nkannan2@wisc.edu