Cortical Reconstruction Using Implicit Surface Evolution (CRUISE)

CRUISE is an automated cortical reconstruction tool using a variation of topology-preserving geometric deformable models (TGDM) called nested TGDM. CRUISE includes the following steps:

1) Starting from a WM mask with a correct topology, inner surface is computed using TGDM that is driven by the filled WM membership.
2) The cortical GM fuzzy membership is enhanced using ACE algorithm.
3) A GVF field is generated from the enhanced cortical GM membership.
4) Starting from the inner surface, central surface is generated using TGDM that is mainly driven by the GVF field computed in the previous step. The nested TGDM approach constrained the evolution in such a way that the final central surface lies outside the inner surface.
5) Starting from the central surface, outer surface is generated by TGDM which is driven by the enhanced cortical GM membership. The outer surfaces is constrained to lie outside the central surface.Input Types

This algorithm requires volumes from the "(Lesion-)TOADS". The "Output" options for (Lesion-)TOADS should be "cruise_inputs"

Input: Classification

WM fill	Combination of membership functions of cerebral WM, sub-cortical GM structures, and ventricles. Filled WM output of (Lesion-)TOADS should be used.
GM	Cortical GM membership generated by (Lesion-)TOADS.
WM mask	Binary mask with a correct topology including cerebral WM, sub-cortical GM structure, and ventricles. Filled WM mask output of (Lesion-)TOADS should be used.

Input: parameters

The parameters for each of the component of CRUISE are completely provided in the individual description page of each algorithm (GVF and nested TGDM)

Example Usage

Example input images from TOADS	Initial Level Set (WM mask)	Filled WM membership	Cortical GM membership
ACE outputs	Thinned ACE Skeleton	ACE Enhanced GM membership
GVF output	Gradient Vector Field (x component)
Nested TGDM outputs (Levelset functions)	Inner Levelset	Central Levelset	Outer Levelset
Nested TGDM outputs (Cortical surfaces)	Inner Surface	Central Surface	Outer Surface