Date: 2008-03-03 21:43 |
Priority: more information 3 |
Submitted By:
David Kennedy (dnkennedy)
|
Assigned To: more information
Nobody (None) |
Pubmed ID: 14615296 | Authors: Takahashi T, Kinsman S, Makris N, Grant E, Haselgrove C, McInerney S, Kennedy DN, Takahashi T, Fredrickson K, Mori S, Caviness VS. |
Citation: Cereb Cortex. 2003 Dec;13(12):1299-312 | URL: http://www.ncbi.nlm.nih.gov/pubmed/14615296 |
Summary: more information Semilobar holoprosencephaly with midline 'seam': a topologic and
morphogenetic model based upon MRI analysis. |
Detailed description |
We present an MRI-based
anatomic analysis of a series of seven human brains with the
semilobar form of holoprosencephaly. The analysis defines a set of
common descriptors for a pattern of topological anomaly which is
uniform for the set of seven brains. The core of the anomaly is a
rostro-caudally aligned midline gray matter 'seam' that extends
from the telencephalic-suprachiasmatic junctional region to abut
the posterior aspect of the callosal commissure. The seam forms the
ventricular roof throughout its extent. Rostrally it is formed by
the conjoined heads of caudate/accumbens nuclei. It continues
caudally as a gray matter bridge in the fundus of the
interhemispheric fissure, where it bridges right and left
neocortex. Fornix, septal nuclei and septal limb of the choroid
plexus are absent, and the telencephalic ventricles communicate
with the diencephalic via open septal limbs of the choroid
fissures. By contrast, the temporal limb of hippocampal formation
and the choroid plexus are normal and the temporal limb of the
choroid fissure is closed. This topological anomaly of conjoined
left and right cortical and nuclear gray matter into a midline seam
and absent septal structures is thus confined to the region of the
midline telencephalic hemisphere evagination. Total telencephalic
growth is strongly correlated with the length of this topologically
abnormal midline telencephalic segment. The set of findings is
consistent with graded failure of induction of rostral to caudal
specification in the midline rostral telencephalic zone.
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