The chronnectome: Evaluating replicability of dynamic connectivity patterns in 7500 resting fMRI datasets.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:5571-5574

Authors: Abrol A, Chaze C, Damaraju E, Calhoun VD

Abstract
Functional fMRI data are typically analyzed under the assumption that participants experience one long, continuous connectivity state throughout rest scan sessions. The chronnectome is a model that takes into account the temporal variance in connectivity throughout a scan session. In this work, we evaluate the repeatability of properties of functional network connectivity (FNC) dynamics assessed using sliding-windowed correlations in 28 independent age-matched large samples of 250 subjects. This approach revealed that multiple discrete, reoccurring connectivity states arise during rest, and that subjects tend to remain in one connectivity state for long periods of time before transitioning to another. Occurrence time spent in certain states tends to increase as participants spend more time resting, while less time is spent in other states as time goes on. Overall, results show distinct connectivity states that are similar across groups during rest.

PMID: 28269517 [PubMed - in process]