dke-questions > Mouse datasets
14 hours ago | Dominika Valášková
Mouse datasets

Hello,
I am trying to process preclinical diffusion data using the DKE and would appreciate some advice. 
I am working with in vivo mouse brain data acquired on a 7T Bruker BioSpec (70/30) scanner running ParaVision360 3.6, using a standard DWI EPI sequence. 
I have tried importing both converted NIfTI files and raw DICOMs into DKE, but I am running into significant issues with the output maps.
Initially, the default spatial smoothing settings were clearly tailored for human data and were far too strong for the small mouse brain. However, even after reducing the filter, the resulting kurtosis maps remain quite "holey", with zero-value voxels or empty regions throughout the brain tissue. 
I am wondering if DKE is actually suitable for small animal data or if it is strictly optimized for human datasets.
Additionally, I would like to know if there are specific pre-processing requirements or data formatting steps for Bruker/ParaVision data that I might be missing, and if anyone can share recommended parameter settings for mouse data. 
Any advice on settings, data import would be greatly appreciated. 
Thanks in advance!
Dominika Valaskova

Attachment: kmean_mouse_DKE.png