Hello,
I am trying to process preclinical diffusion data using the DKE and
would appreciate some advice.
I am working with in vivo mouse brain data acquired on a 7T Bruker
BioSpec (70/30) scanner running ParaVision360 3.6, using a standard
DWI EPI sequence.
I have tried importing both converted NIfTI files and raw DICOMs
into DKE, but I am running into significant issues with the output
maps.
Initially, the default spatial smoothing settings were clearly
tailored for human data and were far too strong for the small mouse
brain. However, even after reducing the filter, the resulting
kurtosis maps remain quite "holey", with zero-value voxels or empty
regions throughout the brain tissue.
I am wondering if DKE is actually suitable for small animal data or
if it is strictly optimized for human datasets.
Additionally, I would like to know if there are specific
pre-processing requirements or data formatting steps for
Bruker/ParaVision data that I might be missing, and if anyone can
share recommended parameter settings for mouse data.
Any advice on settings, data import would be greatly
appreciated.
Thanks in advance!
Dominika Valaskova
