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Current Practice Review
Description: pdf
Updated: Feb 6, 2018
Gannet Manual
Description: Gannet Manual (pdf)
Updated: Feb 6, 2018
Review of Edited MRS
Description: pdf
Updated: Feb 6, 2018
PubMed Mentions ( 53 )+
Beta Peak Frequencies at Rest Correlate with Endogenous GABA+/Cr Concentrations in Sensorimotor Cortex Areas.
Description: Baumgarten, Thomas J, et al. Beta Peak Frequencies at Rest Correlate with Endogenous GABA+/Cr Concentrations in Sensorimotor Cortex Areas. ''PLoS One''. 2016; '''11''' (6):e0156829
Updated: Nov 16, 2019
Dynamics of epileptic activity in a peculiar case of childhood absence epilepsy and correlation with thalamic levels of GABA.
Description: Leal, Alberto, et al. Dynamics of epileptic activity in a peculiar case of childhood absence epilepsy and correlation with thalamic levels of GABA. ''Epilepsy Behav Case Rep''. 2016; '''5''': 57-65
Updated: Nov 16, 2019
Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels.
Description: He, Xuanzi, et al. Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels. ''Biomed Res Int''. 2016; '''2016''': 6523909
Updated: Nov 16, 2019
Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study.
Description: Rowland, L M, et al. Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study. ''Mol Psychiatry''. 2016 Feb; '''21''' (2):198-204
Updated: Nov 16, 2019
GABA deficiency in NF1: A multimodal [11C]-flumazenil and spectroscopy study.
Description: Violante, Ines R, et al. GABA deficiency in NF1: A multimodal [11C]-flumazenil and spectroscopy study. ''Neurology''. 2016 Aug 30; '''87''' (9):897-904
Updated: Nov 16, 2019
Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning.
Description: van Bussel, Frank C G, et al. Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning. ''Medicine (Baltimore)''. 2016 Sep; '''95''' (36):e4803
Updated: Nov 16, 2019
Online Effects of Transcranial Direct Current Stimulation in Real Time on Human Prefrontal and Striatal Metabolites.
Description: Hone-Blanchet, Antoine, et al. Online Effects of Transcranial Direct Current Stimulation in Real Time on Human Prefrontal and Striatal Metabolites. ''Biol Psychiatry''. 2016 Sep 15; '''80''' (6):432-438
Updated: Nov 16, 2019
Perisylvian GABA levels in schizophrenia and bipolar disorder.
Description: Atagun, Murat Ilhan, et al. Perisylvian GABA levels in schizophrenia and bipolar disorder. ''Neurosci Lett''. 2017 Jan 10; '''637''': 70-74
Updated: Nov 16, 2019
Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients.
Description: Baumgarten, Thomas J, et al. Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients. ''Neuroimage Clin''. 2018; '''20''': 347-356
Updated: Nov 16, 2019
No Evidence That Baseline Prefrontal Cortical Excitability (3T-MRS) Predicts the Effects of Prefrontal tDCS on WM Performance.
Description: Talsma, Lotte J, et al. No Evidence That Baseline Prefrontal Cortical Excitability (3T-MRS) Predicts the Effects of Prefrontal tDCS on WM Performance. ''Front Neurosci''. 2018; '''12''': 481
Updated: Nov 16, 2019
Suppression and facilitation of human neural responses.
Description: Schallmo, Michael-Paul, et al. Suppression and facilitation of human neural responses. ''Elife''. 2018 Jan 29; '''7''':
Updated: Nov 16, 2019
Proscription supports robust perceptual integration by suppression in human visual cortex.
Description: Rideaux, Reuben, et al. Proscription supports robust perceptual integration by suppression in human visual cortex. ''Nat Commun''. 2018 Apr 17; '''9''' (1):1502
Updated: Nov 16, 2019
Increased thalamic glutamate/glutamine levels in migraineurs.
Description: Bathel, Adina, et al. Increased thalamic glutamate/glutamine levels in migraineurs. ''J Headache Pain''. 2018 Jul 17; '''19''' (1):55
Updated: Nov 16, 2019
GABA Levels in Left and Right Sensorimotor Cortex Correlate across Individuals.
Description: Puts, Nicolaas A J, et al. GABA Levels in Left and Right Sensorimotor Cortex Correlate across Individuals. ''Biomedicines''. 2018 Jul 24; '''6''' (3):
Updated: Nov 16, 2019
Brain GABA Levels Are Associated with Inhibitory Control Deficits in Older Adults.
Description: Hermans, Lize, et al. Brain GABA Levels Are Associated with Inhibitory Control Deficits in Older Adults. ''J Neurosci''. 2018 Sep 5; '''38''' (36):7844-7851
Updated: Nov 16, 2019
Opposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing.
Description: Kurcyus, Katarzyna, et al. Opposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing. ''J Neurosci''. 2018 Nov 14; '''38''' (46):9967-9976
Updated: Nov 16, 2019
Low Prefrontal GABA Levels Are Associated With Poor Cognitive Functions in Professional Boxers.
Description: Kim, Geon Ha, et al. Low Prefrontal GABA Levels Are Associated With Poor Cognitive Functions in Professional Boxers. ''Front Hum Neurosci''. 2019; '''13''': 193
Updated: Nov 16, 2019
Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy.
Description: Li, Yan, et al. Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy. ''BMC Psychiatry''. 2019 May 30; '''19''' (1):164
Updated: Nov 16, 2019
The effectiveness and safety of Kami Guibi-tang for mild cognitive impairment: study protocol of a pilot, randomized, placebo-controlled, double-blind trial.
Description: Shin, Hee-Yeon, et al. The effectiveness and safety of Kami Guibi-tang for mild cognitive impairment: study protocol of a pilot, randomized, placebo-controlled, double-blind trial. ''Trials''. 2019 Jul 22; '''20''' (1):448
Updated: Nov 16, 2019
Cervical Dystonia Is Associated With Aberrant Inhibitory Signaling Within the Thalamus.
Description: Groth, Christopher L, et al. Cervical Dystonia Is Associated With Aberrant Inhibitory Signaling Within the Thalamus. ''Front Neurol''. 2020; '''11''': 575879
Updated: Apr 10, 2021
Prefrontal GABA Levels Correlate with Memory in Older Adults at High Risk for Alzheimer's Disease.
Description: Murari, Geetanjali, et al. Prefrontal GABA Levels Correlate with Memory in Older Adults at High Risk for Alzheimer's Disease. ''Cereb Cortex Commun''. 2020; '''1''' (1):tgaa022
Updated: Aug 14, 2021
Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder.
Description: Poletti, Sara, et al. Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder. ''Front Psychiatry''. 2020; '''11''': 590095
Updated: Jan 23, 2021
Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study.
Description: Nwaroh, Chidera, et al. Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study. ''PLoS One''. 2020; '''15''' (1):e0222620
Updated: Feb 15, 2020
Feasibility of Measuring GABA Levels in the Upper Brainstem in Healthy Volunteers Using Edited MRS.
Description: Song, Yulu, et al. Feasibility of Measuring GABA Levels in the Upper Brainstem in Healthy Volunteers Using Edited MRS. ''Front Psychiatry''. 2020; '''11''': 813
Updated: Oct 17, 2020
Fitness Level Influences White Matter Microstructure in Postmenopausal Women.
Description: Harasym, Diana, et al. Fitness Level Influences White Matter Microstructure in Postmenopausal Women. ''Front Aging Neurosci''. 2020; '''12''': 129
Updated: Jul 18, 2020
The neurometabolic profiles of GABA and Glutamate as revealed by proton magnetic resonance spectroscopy in type 1 and type 2 diabetes.
Description: d'Almeida, Otilia C, et al. The neurometabolic profiles of GABA and Glutamate as revealed by proton magnetic resonance spectroscopy in type 1 and type 2 diabetes. ''PLoS One''. 2020; '''15''' (10):e0240907
Updated: Nov 14, 2020
Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression.
Description: Mak, Arthur D P, et al. Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression. ''Front Psychiatry''. 2020; '''11''': 549749
Updated: Nov 14, 2020
Weaker neural suppression in autism.
Description: Schallmo, Michael-Paul, et al. Weaker neural suppression in autism. ''Nat Commun''. 2020 May 29; '''11''' (1):2675
Updated: Jul 18, 2020
Optimized truncation to integrate multi-channel MRS data using rank-R singular value decomposition.
Description: Sung, Dongsuk, et al. Optimized truncation to integrate multi-channel MRS data using rank-R singular value decomposition. ''NMR Biomed''. 2020 Jul; '''33''' (7):e4297
Updated: Jul 18, 2020
Temporal Dynamics of GABA and Glx in the Visual Cortex.
Description: Rideaux, Reuben. Temporal Dynamics of GABA and Glx in the Visual Cortex. ''eNeuro''. 2020 Jul/Aug; '''7''' (4):
Updated: Aug 29, 2020
Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder.
Description: Umesawa, Yumi, et al. Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder. ''J Autism Dev Disord''. 2020 Aug; '''50''' (8):2710-2722
Updated: Aug 29, 2020
Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults.
Description: King, Bradley R, et al. Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults. ''Hum Brain Mapp''. 2020 Sep; '''41''' (13):3680-3695
Updated: Aug 29, 2020
GABA, noise and gain in human visual cortex.
Description: Hammett, Stephen T, et al. GABA, noise and gain in human visual cortex. ''Neurosci Lett''. 2020 Sep 25; '''736''': 135294
Updated: Oct 17, 2020
Treatment response after 6 and 26 weeks is related to baseline glutamate and GABA levels in antipsychotic-naive patients with psychosis.
Description: Bojesen, Kirsten B, et al. Treatment response after 6 and 26 weeks is related to baseline glutamate and GABA levels in antipsychotic-naive patients with psychosis. ''Psychol Med''. 2020 Oct; '''50''' (13):2182-2193
Updated: Nov 14, 2020
Assessing differential effects of single and accelerated low-frequency rTMS to the visual cortex on GABA and glutamate concentrations.
Description: Rafique, Sara A, et al. Assessing differential effects of single and accelerated low-frequency rTMS to the visual cortex on GABA and glutamate concentrations. ''Brain Behav''. 2020 Dec; '''10''' (12):e01845
Updated: Jan 23, 2021
Cerebellar GABA Levels and Cognitive Interference in Parkinson's disease and Healthy Comparators.
Description: Piras, Federica, et al. Cerebellar GABA Levels and Cognitive Interference in Parkinson's disease and Healthy Comparators. ''J Pers Med''. 2020 Dec 28; '''11''' (1):
Updated: Feb 13, 2021
Changes in Prefrontal Gamma-Aminobutyric Acid and Perfusion After the Computerized Relaxation Training in Women With Psychological Distress: A Preliminary Report.
Description: Namgung, Eun, et al. Changes in Prefrontal Gamma-Aminobutyric Acid and Perfusion After the Computerized Relaxation Training in Women With Psychological Distress: A Preliminary Report. ''Front Psychol''. 2021; '''12''': 569113
Updated: May 15, 2021
Dissociable effects of age and Parkinson's disease on instruction-based learning.
Description: Parkin, Beth L, et al. Dissociable effects of age and Parkinson's disease on instruction-based learning. ''Brain Commun''. 2021; '''3''' (3):fcab175
Updated: Oct 16, 2021
GABA, Glutamate, and NAA Levels in the Deep Cerebellar Nuclei of Essential Tremor Patients.
Description: Buijink, Arthur W G, et al. GABA, Glutamate, and NAA Levels in the Deep Cerebellar Nuclei of Essential Tremor Patients. ''Front Neurol''. 2021; '''12''': 664735
Updated: Jun 19, 2021
Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive-Compulsive Disorder.
Description: Batistuzzo, Marcelo C, et al. Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive-Compulsive Disorder. ''Front Psychiatry''. 2021; '''12''': 668304
Updated: Oct 16, 2021
Multimodal Neuroimaging Study of Visual Plasticity in Schizophrenia.
Description: Wijtenburg, S Andrea, et al. Multimodal Neuroimaging Study of Visual Plasticity in Schizophrenia. ''Front Psychiatry''. 2021; '''12''': 644271
Updated: May 15, 2021
Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample.
Description: Bell, Tiffany, et al. Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample. ''Sci Rep''. 2021 Jan 12; '''11''' (1):722
Updated: Feb 13, 2021
Sensory over-responsivity is related to GABAergic inhibition in thalamocortical circuits.
Description: Wood, Emily T, et al. Sensory over-responsivity is related to GABAergic inhibition in thalamocortical circuits. ''Transl Psychiatry''. 2021 Jan 12; '''11''' (1):39
Updated: Feb 13, 2021
The neurobiology of wellness: (1)H-MRS correlates of agency, flexibility and neuroaffective reserves in healthy young adults.
Description: White, Tara L, et al. The neurobiology of wellness: (1)H-MRS correlates of agency, flexibility and neuroaffective reserves in healthy young adults. ''Neuroimage''. 2021 Jan 15; '''225''': 117509
Updated: Mar 20, 2021
Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site.
Description: Mezger, Eva, et al. Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site. ''Eur Arch Psychiatry Clin Neurosci''. 2021 Feb; '''271''' (1):111-122
Updated: Mar 20, 2021
On the functional role of striatal and anterior cingulate GABA+ in stimulus-response binding.
Description: Takacs, Adam, et al. On the functional role of striatal and anterior cingulate GABA+ in stimulus-response binding. ''Hum Brain Mapp''. 2021 Apr 15; '''42''' (6):1863-1878
Updated: Apr 10, 2021
Comparison of methods for spectral alignment and signal modelling of GABA-edited MR spectroscopy data.
Description: Rideaux, Reuben, et al. Comparison of methods for spectral alignment and signal modelling of GABA-edited MR spectroscopy data. ''Neuroimage''. 2021 May 15; '''232''': 117900
Updated: Oct 16, 2021
Simultaneous quantification of GABA, Glx and GSH in the neonatal human brain using magnetic resonance spectroscopy.
Description: Maria, Yanez Lopez, et al. Simultaneous quantification of GABA, Glx and GSH in the neonatal human brain using magnetic resonance spectroscopy. ''Neuroimage''. 2021 Jun; '''233''': 117930
Updated: Oct 16, 2021
Kisspeptin modulates gamma-aminobutyric acid levels in the human brain.
Description: Comninos, Alexander N, et al. Kisspeptin modulates gamma-aminobutyric acid levels in the human brain. ''Psychoneuroendocrinology''. 2021 Jul; '''129''': 105244
Updated: Oct 16, 2021
Focal corticarl dysplasia in epilepsy is associated with GABA increase.
Description: Gong, Tao, et al. Focal corticarl dysplasia in epilepsy is associated with GABA increase. ''Neuroimage Clin''. 2021 Jul 14; '''31''': 102763
Updated: Aug 14, 2021
Region-specific elevations of glutamate + glutamine correlate with the sensory symptoms of autism spectrum disorders.
Description: He, Jason L, et al. Region-specific elevations of glutamate + glutamine correlate with the sensory symptoms of autism spectrum disorders. ''Transl Psychiatry''. 2021 Jul 29; '''11''' (1):411
Updated: Oct 16, 2021
Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation.
Description: Gann, Mareike A, et al. Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation. ''Neuroimage''. 2021 Aug 15; '''237''': 118158
Updated: Oct 16, 2021
Brain gamma-aminobutyric acid, but not glutamine and glutamate levels are lower in older adults with chronic musculoskeletal pain: considerations by sex and brain location.
Description: Cruz-Almeida, Yenisel, et al. Brain gamma-aminobutyric acid, but not glutamine and glutamate levels are lower in older adults with chronic musculoskeletal pain: considerations by sex and brain location. ''Pain Rep''. 2021 Sep-Oct; '''6''' (3):e952
Updated: Oct 16, 2021