Dear NITRC community,

Our lab is working with the MRTool toolbox in SPM12 to calculate the T1/T2 ratio for a neurodevelopmental sample. MRTool uses linear scaling and nonlinear scaling with histogram matching to calibrate the T1 and T2 images before taking the ratio. Since we are using longitudinal data, we want to use a common intensity calibration for each subject instead of calibrating each subject's individual timepoint separately. Is there a way we could achieve this? For example, we have used SPM to create an average T1 image for each subject, and were wondering if it would be possible to calibrate each individual session T1 and T2 using the average image in MRTool.

Any help would be greatly appreciated,

Hannah