Dear Dr Chopra,

Apologies for the late reply. The default and recommended FWER correction in SDM-PSI is the "threshold-free cluster enhancement" (TFCE), and TFCE does depend on the mask. Therefore, we would strongly suggest restrict all SDM analyses to the cerebellum.

The use of a new mask is not straightforward, because SDM-PSI also needs a special binary file that contains information about the neighboring voxels of each voxel within the mask. That said, if you send us the mask of the cerebellum that you would like to use, we can create and send you the appropriate files to run SDM restricted to the cerebellum.

With best regards,

Joaquim