Dear Lydia,

Thank you for your response!

I'm still wondering that if it is reasonable that a brain region was reported in the combined multimodal results but not reported in previous separate analysis. For example, we explored the disorder A and disorder B. Patients with disorder A showed abnormality in prefrontal cortex, but disorder B does not report changes in prefrontal cortex or adjacent brain regions. Then, we performed multimodal analysis between disorder A and disorder B. The results of multimodal analysis exhibited abnormality in prefrontal cortex. This result makes us confused. Why results not reported in disease B appeared in the multimodal results. I’m not sure whether we performed the analysis correctly or do you have any other suggestions please let us know.

Your help and advice would be much appreciated!

You.