Hello expert,

 

I have a question about fMRI connectivity analysis.

I’m trying to see if connectivity differs between groups of patient and controls, in a set of ROI.

 

Say I'd use correlation 

 

My issue is that the fMRI timeseries are much longer for the control than patients, about 2 times longer, so more timepoints (~480 vs ~250); it's a feature of the task they were doing, the patients got fatigued much earlier. So, the correlation for the controls would be computed with more timepoints than the correlation of the patients.

 

-1-

So, my question is since the number of timepoints differ substantially between the groups, is this a problem for group analysis? I would compare the correlation between groups with a t-test for example.

 

-2-

If this an issue, is there a way out? Maybe up-sampling the patient time series or some other methods?

 

 

thansk a lot

patrick