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Notes:
Introducing CANDIShare Schiz_Bull_2008 Version
1.1. With this release we have added the CMA 'general'
segmentation for all 103 subjects in the prior V1.0 release.
We include the preprocessed MRI images and
segmentation results of all 4 diagnostic groups (Healthy Controls
(N=29), Schizophrenia Spectrum (N=20), Bipolar Disorder with
Psychosis (N=19), and Bipolar Disorder without Psychosis (N=35))
from the article: Frazier JA, Hodge SM, Breeze JL, Giuliano AJ,
Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS,
Seidman LJ, Zablotsky B, Makris N. Diagnostic and sex effects
on limbic volumes in early-onset bipolar disorder and
schizophrenia. Schizophr Bull. 2008 Jan;34(1):37-46.
The release contains 4 files, one for each diagnostic group,
provided as a gziped tar file of a set of directories containing
the data.
The root directory is for the paper, SchizBull_2008/, and
contains subdirectories for the 4 diagnostic groups: Healthy
Controls (HC), bipolar disorder without psychosis (BPDwithoutPsy),
bipolar disorder with psychosis (BPDwithPsy) and schizophrenia
spectrum (SS). Each of these subdirectories will contain separate
subdirectories for each subject. These subject directories contain
the CMA preprocessed image that was submitted to the anatomic
segmentation process, and the results of the general segmentation.
These files are of type NIfTI (nii.gz) and called
{$SUBJECT_ID}_{$TYPE}.nii.gz; where $TYPE is 'procimg' for
preprocessed images, and 'seg' for general segmentation. The seg
results are 'n-ary' images, where the fill value represents the
specific anatomic region.
Each of the diagnostic group tar files will 'unpack' onto the same
directory structure and fill in the released subset of data.
The nature of the CMA preprocessing includes positional
normalization to put the image into the standard orientation of the
Talairach coordinate space, and bias field correction as described
in: Worth AJ, Makris N, Patti MR, Goodman JM, Hoge EA, Caviness VS
Jr, Kennedy DN. Precise segmentation of the lateral ventricles and
caudate nucleus in MR brain images using anatomically driven
histograms. IEEE Trans Med Imaging. 1998
Apr;17(2):303-10.
The basic segmentation
procedures followed by the CMA are overviewed in: Filipek
PA, Richelme C, Kennedy DN, Caviness VS Jr., The young adult human
brain: an MRI-based morphometric analysis. Cereb
Cortex. 1994 Jul-Aug;4(4):344-60.
Diagnostic group basic demographic information
is provided in the diagnostic subdirectory in a .csv file
entitled {$DIAG}_Basic_Demographics.csv. This file contains
age, gender, and handedness for each of the subjects in the
diagnostic group.
The fill value codes for the 'seg'
files can be found in the 'seg_fill_values.txt' file to be found in
the Documents section of the CANDIShare NITRC project. The
fill values are correct for automatic interpretation using the 'CMA
Subcortical' color pallet in fslview and the Freesurfer
'FreeSurferColorLUT.txt'.
Changes:
Changed in V1.1:
- added CMA 'general' segmentation files for all subjects,
- require 'Registration and Collect Contact Info' for
distribution
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