ADIDP: Testing Genetically-Regulated Imaging Phenotypes in Neurodegenerative Disease

This resource provides R code for implementing association testing of imaging derived phenotypes (IDPs) in neurodegenerative diseases, such as Alzheimer's Disease, using Genome Wide Association Study summary statistics. This resource utilizes many existing packages for phenotype testing, including Mendelian Randomization, the Sum of Powered Score Tests, and the adaptive Sum of Powered Score Test. This code directly mirrors the analysis pipeline implemented in "Knutson, K.A., Pan, W. Integrating brain imaging endophenotypes with GWAS for Alzheimer’s disease. Quant Biol (2020).




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