The MNI-HISUB25 dataset contains manual hippocampal subfield labels and associated high-resolution MRI data (submillimetric T1- and T2-weighted images, detailed sequence information, and stereotaxic probabilistic anatomical maps) based on 25 healthy subjects. Data were acquired on a 3-Tesla MRI system using a 32 phased-array head coil. The protocol divided the hippocampal formation into three subregions: subicular complex, Cornu Ammonis 1, 2 and 3 (CA1-3), and CA4-dentate gyrus (CA4-DG). Segmentation was guided by consistent intensity and morphology characteristics of the densely myelinated molecular layer together with few geometry-based boundaries flexible to overall mesiotemporal anatomy, and achieved excellent intra-/inter-rater reliability (Dice index ≥90/87%). The dataset can inform neuroimaging assessments of the mesiotemporal lobe and help to develop segmentation algorithms relevant for basic and clinical neurosciences.
Funding: See the following article for details regarding subjects, scan
acquisition and preprocessing steps:
Kulaga-Yoskovitz, J., Bernhardt, B.C., Hong, S., Mansi, T., Liang,
K., van der Kouwe, A.J.W., Smallwood J., Bernasconi A., Bernasconi
N. Multi-contrast and submillimetric 3-Tesla hippocampal subfield
segmentation protocol and dataset. Scientific data, in press.
This work and BCB were supported by the Canadian Institutes of
Health Research (CIHR MOP-57840 and CIHR MOP-123520).