users > Original CMTK GUI and Parallel CMTK GUI not working on Mac 13.7.8
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Aug 6, 2026  06:08 PM | Tristan Stoyanof
Original CMTK GUI and Parallel CMTK GUI not working on Mac 13.7.8

Hi All,


We had historically used the Jeffries CMTK GUI on our Mac, but a recent forced IT update has thrown it all out of whack. When using it, it generates a "commands" folder as normal, but won't populate it with a written script.


I then tried the newer parallel GUI, using the "Full Flybrain" + "Affine and Warp Registration" options and settings similar to what we've run in the past, even though most of the settings won't change when using the preset (we've used the OG GUI to register zebrafish brains numerous times). Whenever I run that, both the warp and affine steps immediately fail, and so zero images are reformatted.


I've checked the folder/file naming conventions. There are no spaces, no underscores except for just before the channel names, and no special characters. Any clue as to what could be driving the issues?


The OS is Ventura 13.7.8, and all of the CMTK files seem to be the most updated versions possible.
I appreciate any help possible!

Aug 7, 2026  08:08 AM | Sandor Kovacs
RE: Original CMTK GUI and Parallel CMTK GUI not working on Mac 13.7.8

Hi, 


The Mac Version is a bit neglected at this point, I dont have the hardware currently, you can help with a bit of troubleshooting though. Can you try to run a simple cmtk command like cmtk - - help, or something from the CMTK user guide by Torsten and tell us the result? Also can you tell me the path of the CMTK/bin folder? Thanks! 

Aug 7, 2026  08:08 AM | Greg Jefferis
RE: Original CMTK GUI and Parallel CMTK GUI not working on Mac 13.7.8

The unofficial GitHub repo now includes regular builds for Mac and Linux. If you have trouble with the Mac build from nitrc this could be helpful 


https://github.com/jefferis/cmtk/tree/natdev

best,


greg. 

Aug 7, 2026  04:08 PM | Tristan Stoyanof
RE: Original CMTK GUI and Parallel CMTK GUI not working on Mac 13.7.8

Originally posted by Sandor Kovacs:



Hi, 


The Mac Version is a bit neglected at this point, I dont have the hardware currently, you can help with a bit of troubleshooting though. Can you try to run a simple cmtk command like cmtk - - help, or something from the CMTK user guide by Torsten and tell us the result? Also can you tell me the path of the CMTK/bin folder? Thanks! 



I apologize because I'm very non-tech savvy. I downloaded the newer CMTK that Greg pointed to, when unzipped it becomes a .dmg file. Within, there's a CMTK folder and instructions to move it to the Applications folder, which I've done. I've also moved a copy of that new CMTK folder to Desktop/Fiji/bin/CMTK, but I'm not tech literate enough to know how to use this updated CMTK donwload correctly. Additionally, I was struggling to get the cmtk --help command to work, even after changing the directory to those two I just described.


Thanks again for the help and patience!

Aug 16, 2026  02:08 PM | Sandor Kovacs
RE: Original CMTK GUI and Parallel CMTK GUI not working on Mac 13.7.8

Hi, 

I added some changes, there are now automatic and manual tools to help the user discover the right cmtk binaries. It may not be the solution but worth testing:

https://github.com/sandorbx/Parallel-Fiji-CMTK-Registration/tree/fix/mac-cmtk-discovery

Please report back either way, Thank you!

Aug 16, 2026  05:08 PM | Tristan Stoyanof
RE: Original CMTK GUI and Parallel CMTK GUI not working on Mac 13.7.8

Thank you so much! I'll give it a try this week and report back. We ended up dedicating a Windows PC to CMTK in the meantime, and it was much easier to set up (once I figured out I needed WSL 2 installed).


I'll see if I can get it working on the Mac, and at the very least be the guinea pig for this new set of instructions. I'm moving to a new lab soon, but I'll make sure the next user gets all this too!