Hi,

As I was reading through several papers on Compcor, I was a bit confused on when the spatial smoothing via Gaussian kernel comes into play.
In 2012 paper by Chai et al, the spatial smoothing comes before aCompCor, whereas in 2014 paper by Muschelli et al, the step comes at the end, after all the regressions have been run.

Although I suspect that there is no 'correct' answer, I was wondering which approach is preferable for what reasons.

Thanks for the help!