Dear all

I understood that NiiStat assumes lesions to be associated with decreased performance. In fact it is described that regions or voxels associated with better behavioral performance are ignored.

I first applied the FDR for correction of multiple comparisons and it described the confidence interval like this:
q=0.0500 FDR correction for PFT with 159 tests is z<-3.76274587, z>Inf
which I undestand as it is one-tailed.

Then I applied Normal Permutation for correction of multiple comparisons and it described the confidence interval like this:
p<0.050 permutation correction for PFT is z<-2.41413 z>3.73859
which confuses me as the Z-value can be positiv and means that the increase in lesion is associated with increase in performance.

Is it legitimate to interpret a positive z-value for a specific test in a specific ROI as an indication for increased performance in case of lesion in this area?

Best,
Magdalena