Hi Ole, 

You may also want to test the contrast 0 -1 0 0 0. 

Other than that, everything looks ok. 

Andrew

Originally posted by Ole Jonas Böken:

Dear Prof. Zalesky,

I’d like to confirm a GLM setup in NBS to test whether time since onset (TSO) is associated with connectivity in patients, adjusting for age and sex (and optionally scanning protocol - because different scanners were used-, binary).

Column order: Intercept zTSO zAge Sex Prot
t-contrast for TSO: 0 1 0 0 0

Design matrix excerpt (first 5 rows):
1 0.8946343228017042 -0.004561935982568295 0 1
1 -0.6792377931049878 -0.04470697262916825 0 1
1 1.0143854620554744 -1.4096382186135632 0 0
1 -0.9529546828278908 0.2898349994258306 0 1
1 -0.8674181547894837 -0.6736458800925659 0 1

Questions:

• 
  

  Is this design and contrast correct for testing the TSO effect in patients only?

  
  


• 
  

  If I drop Prot when constant, I would use: Intercept zTSO zAge Sex; contrast: 0 1 0 0. Is that appropriate?

  
  

Thanks in advance,

Ole