Hi Yihe, 

Both options are reasonable - post hoc tests and running one-sided t-tests. It really depends on the goals of your analyses. 

Given that you have identified a relatively large network (900 edges), running two independent, one-sided t-tests may be helpful to localize the positive and negative effects. On the other hand the effects may be genuinely diffuse and not localisable by their nature.

You could consider summary measures such as the degree of nodes in the 900 edge graph, to make the interpretation of effects more manageable. 

Kind regards, 

Andrew 

Originally posted by yihe weng:

Dear Andrew,

I came across one of your previous responses to a similar question, which I found very helpful. You mentioned that it is reasonable to run t-tests on each edge as a post-hoc analysis.
For example, if I identified around 900 significant edges for the main effect of A using the F-test, should I perform t-tests on each edge between A1 and A2 to separate the network into edges showing higher connectivity in A1 than A2 and those showing higher connectivity in A2 than A1?

Many thanks again!

Best,
Yihe