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help > RE: Discrepancy between subnetwork and raw connectivity data
Oct 13, 2020 11:10 PM | Andrew Zalesky
RE: Discrepancy between subnetwork and raw connectivity data
Hi Jean,
You may want to check your contrast and design matrix.
If your contrast is Control > Disease, all edges comprising any significant network should be consistent with this contrast (i.e. mean edge strength should be greater in Controls compared to Disease), unless confounds are having a significant impact.
One possibility is that your design matrix includes confounds/co-variates, which have a significant impact. So, I would suggest to run without any confounds as well.
Andrew
Originally posted by YaeJi Kim:
You may want to check your contrast and design matrix.
If your contrast is Control > Disease, all edges comprising any significant network should be consistent with this contrast (i.e. mean edge strength should be greater in Controls compared to Disease), unless confounds are having a significant impact.
One possibility is that your design matrix includes confounds/co-variates, which have a significant impact. So, I would suggest to run without any confounds as well.
Andrew
Originally posted by YaeJi Kim:
Dear NBS experts,
Hello! First of all, thank you for the great analysis tool.
I have a question regarding the output of subnetwork and its raw connectivity edge strength of input.
I got a subnetwork with contrasting Control group > Disease group , but as I checked the raw edge strength of the significant subnetwork, the mean value of the strength is greater in Disease group than Control group. Which is opposite directionality from the subnetwork.
How can I explain this discrepancy?
I believed I was confident in NBS, but now I am quite confusing.
Is this a problem of my data?
Please please give me a feedback on this issue.
Thank you!
Sincerely,
Jean.
Hello! First of all, thank you for the great analysis tool.
I have a question regarding the output of subnetwork and its raw connectivity edge strength of input.
I got a subnetwork with contrasting Control group > Disease group , but as I checked the raw edge strength of the significant subnetwork, the mean value of the strength is greater in Disease group than Control group. Which is opposite directionality from the subnetwork.
How can I explain this discrepancy?
I believed I was confident in NBS, but now I am quite confusing.
Is this a problem of my data?
Please please give me a feedback on this issue.
Thank you!
Sincerely,
Jean.
Threaded View
| Title | Author | Date |
|---|---|---|
| YaeJi Kim | Oct 13, 2020 | |
| Andrew Zalesky | Oct 13, 2020 | |
| YaeJi Kim | Oct 14, 2020 | |
| Andrew Zalesky | Oct 14, 2020 | |