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help > RE: Power analysis for NBS
Nov 24, 2020 12:11 AM | Andrew Zalesky
RE: Power analysis for NBS
Hi Paul,
I suggest performing the sample size calculation for a single connection using existing power calculators for univariate tests. This will most likely yield a conservative estimate of the required sample size because evidence that accumulates across multiple connections comprising a subnetwork is not considered in this calculation (although this is not guaranteed).
Exact power calculations are challenging in these circumstances.
The average effect size across a subnetwork could be used as a crude effect size estimate for the univariate sample size calculation. Remember that the effect size estimate will most likely be inflated when inferred from a small sample.
Andrew
Originally posted by Paul Thomas:
I suggest performing the sample size calculation for a single connection using existing power calculators for univariate tests. This will most likely yield a conservative estimate of the required sample size because evidence that accumulates across multiple connections comprising a subnetwork is not considered in this calculation (although this is not guaranteed).
Exact power calculations are challenging in these circumstances.
The average effect size across a subnetwork could be used as a crude effect size estimate for the univariate sample size calculation. Remember that the effect size estimate will most likely be inflated when inferred from a small sample.
Andrew
Originally posted by Paul Thomas:
Hello all,
I was wondering if anyone knows how to go about doing a power analysis for either experiments conducted with NBS to determine power, or just generally to determine whether, given a sample size, desired effect size, etc., one has adequate power. For example, is it as simple as conducting a power analysis on the statistical test used on each edge? I guess I am confused on how to determine the effect size of an NBS-defined subnetwork. Any input is appreciated.
Thank you,
Paul
I was wondering if anyone knows how to go about doing a power analysis for either experiments conducted with NBS to determine power, or just generally to determine whether, given a sample size, desired effect size, etc., one has adequate power. For example, is it as simple as conducting a power analysis on the statistical test used on each edge? I guess I am confused on how to determine the effect size of an NBS-defined subnetwork. Any input is appreciated.
Thank you,
Paul
Threaded View
| Title | Author | Date |
|---|---|---|
| Paul Thomas | Nov 23, 2020 | |
| Andrew Zalesky | Nov 24, 2020 | |
| Paul Thomas | Nov 24, 2020 | |