Here is one design matrix (attached).

And this one other one which is this one would be more of an interaction approach? 

1 91 91
1 89 89
1 90 90
1 67 67
1 84 84
1 103 103
1 86 86
1 59 59
1 113 113
1 86 86
1 90 90
1 56 56
1 94 94
1 80 80
0 111 0
0 111 0
0 98 0
0 90 0
0 110 0
0 98 0
0 106 0
0 99 0
0 97 0
0 117 0
0 109 0
0 132 0
0 97 0
0 110 0

I am still trying to figure out which way to design the matrix. Whether looking at the difference between patients and controls or rather an interaction?