help > Uploading Preprocessed Data
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Nov 5, 2025  04:11 PM | Grace Hodges - Ohio State University Wexner Medical Center
Uploading Preprocessed Data

Hi,


I have some data that has already been preprocessed and denoised, and I would like to use the CONN analysis tools but I am unable to skip preprocessing and denoising steps in the toolbox (v 21 and 22). I have made a few attempts to circumvent those steps for this data, but it keeps outputting misaligned data and/or re-denoising already-denoised data. Do you have any recommendations as to how to upload preprocessed data to use the CONN analysis tools?


 


I have attached the preprocessing and denoising steps that have gotten closest to what I want to do, please let me know what suggestions you have to fix it.


 


Thanks,


Grace

Attachment: CONNpipeline.pdf
  Edited (Nov 5, 2025  04:11 PM)
Nov 7, 2025  07:11 PM | Alfonso Nieto-Castanon - Boston University
RE: Uploading Preprocessed Data

Hi Grace,


Please provide more information about how your data was preprocessed/denoised to be able to help you, but in general it is perfectly fine to enter already preprocessed and denoised data into CONN. If it is fully preprocessed and denoised, all that you need to do is enter the corresponding MNI-space anatomical and functional data (unless you want to be able to run quality control and evaluate the quality of your data before running any analyses, which is definitely recommended, in which case you also want to import other outputs of your preprocessing pipeline into CONN, like MNI-space gray/white/csf segmentation masks, realignment parameters, framewise displacement, potential outlier scans, etc. ) and simply skip both preprocessing and denoising. To skip preprocessing, simply do not run the preprocessing step and move directly to the denoising tab after importing your data, and to skip denoising simply remove all of the denoising steps set up by default in the Denoising tab.


Hope this helps


Alfonso


Originally posted by Grace Hodges:



Hi,


I have some data that has already been preprocessed and denoised, and I would like to use the CONN analysis tools but I am unable to skip preprocessing and denoising steps in the toolbox (v 21 and 22). I have made a few attempts to circumvent those steps for this data, but it keeps outputting misaligned data and/or re-denoising already-denoised data. Do you have any recommendations as to how to upload preprocessed data to use the CONN analysis tools?


 


I have attached the preprocessing and denoising steps that have gotten closest to what I want to do, please let me know what suggestions you have to fix it.


 


Thanks,


Grace



 

Nov 7, 2025  09:11 PM | Grace Hodges - Ohio State University Wexner Medical Center
RE: Uploading Preprocessed Data

Hi,


 


In the versions I have used I have been unable to skip steps. For each tab to "open" I have to run the tab before, forcing me to run all levels to some extent. Do you know what version allows me to skip steps and/or what settings to put in order to be able to skip steps?

  Edited (Nov 10, 2025  07:11 PM)
Nov 10, 2025  07:11 PM | Grace Hodges - Ohio State University Wexner Medical Center
RE: Uploading Preprocessed Data

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  Edited (Nov 10, 2025  08:11 PM)
Dec 9, 2025  10:12 PM | Alfonso Nieto-Castanon - Boston University
RE: Uploading Preprocessed Data

Hi Grace


Sorry that was not clear, all versions allow you to skip preprocessing and/or denoising. You still need to run through the Setup/Denoising/First-level/etc. steps, but you can set those steps up to basically do nothing to your data. In particular, in the Setup tab, simply do not click on the Preprocessing button if you do not want to run any preprocessing step on your data (but press 'Done' to move on to denoising), and in the denoising step, since the settings there will default to the options necessary to run aCompCor, scrubbing, etc., simply change the settings in that tab to ask CONN to do nothing (basically remove all of the effects in the 'Confounds' list, set the band-pass filter to [0 inf], and select 'no detrending' (and then again press 'Done' to move on to first-level analyses)


Hope this helps


Alfonso


Originally posted by Grace Hodges:



Hi,


 


In the versions I have used I have been unable to skip steps. For each tab to "open" I have to run the tab before, forcing me to run all levels to some extent. Do you know what version allows me to skip steps and/or what settings to put in order to be able to skip steps?