help > Ave. Conn w/ Cluster Contrasted Across Subjects Scale Question
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Nov 28, 2025  06:11 PM | Jeff Browndyke
Ave. Conn w/ Cluster Contrasted Across Subjects Scale Question

Hello fellow CONN people,


I was wondering what the scale may denote when one uses the "Average Connectivity w/ Cluster Contrasted Across Subjects" graphic function but the subject factor isn't a group-wise contrast but a correlation/regression?


For instance, I ran a MVPA regression (0 1 0 0) and found a significant cluster.  When I select the graphic function option using this cluster as a seed and the same regression model weights, the scale is -0.06 to 0.06 r and the legend states it reflects a diff r, but again the subject-wise model used to generate the maps was correlation w/ my values-of-interest (i.e., 0 1 0 0; AllSubj, Values-of-interest, Age, QAfactor).  

Thanks for any help or thoughts,


Jeff Browndyke

Dec 9, 2025  10:12 PM | Alfonso Nieto-Castanon - Boston University
RE: Ave. Conn w/ Cluster Contrasted Across Subjects Scale Question

Hi Jeff,


Those plots always show the effect-size of your GLM model, so for a regression analysis (e.g. with factors [AllSubects, SeverityScore, Age, QAfactor] and a [0,1,0,0]), the color will scale with the values of regressor coefficients associated with the second factor in that model and estimated at each voxel. The units of those coefficients in a regression model are in "difference in r per unit change in your regressor" (e.g. r-change divided by SeverityScore-change), so you are right the "r diff" name is a bit misleading, sorry.


Hope this helps


Alfonso


Originally posted by Jeff Browndyke:



Hello fellow CONN people,


I was wondering what the scale may denote when one uses the "Average Connectivity w/ Cluster Contrasted Across Subjects" graphic function but the subject factor isn't a group-wise contrast but a correlation/regression?


For instance, I ran a MVPA regression (0 1 0 0) and found a significant cluster.  When I select the graphic function option using this cluster as a seed and the same regression model weights, the scale is -0.06 to 0.06 r and the legend states it reflects a diff r, but again the subject-wise model used to generate the maps was correlation w/ my values-of-interest (i.e., 0 1 0 0; AllSubj, Values-of-interest, Age, QAfactor).  

Thanks for any help or thoughts,


Jeff Browndyke