Hello CONN experts,

I would like to analyze BOLD signal variations both within white matter and within white matter lesions in patients with multiple sclerosis.
To do this, however, I would like to know:
1. How to import white matter lesions into CONN?
2. How to leave lesions in either subject space or MNI space in CONN?
3. Is an ALFF/fALFF analysis in CONN recommended to evaluate BOLD signal variations between patients and between the lesion and the intact part of the white matter?
4. Which CONN parameters should I use to preprocess the white matter signal compared to the gray matter signal?
5. Are there any aspects I should take into consideration regarding CONN?

Thank you,

Alberto 

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This is a really interesting research topic. Analyzing white matter signals and lesions definitely requires careful preprocessing and interpretation.