Posted By: Judith Rumsey - Sep 10, 2009
Tool/Resource: NIH Pediatric MRI Data Repository
NIH Pediatric MRI Data Repository Announces Third Release of Data

This third release includes longitudinal anatomic MRI and MR spectroscopy data for ages 7 days through young adult.

The NIH Pediatric MRI Data Repository has released its third set of data from the NIH Pediatric Magnetic Resonance Imaging (MRI) Study of Normal Brain Development, an effort to establish a database of magnetic resonance imaging and correlated clinical/behavioral data reflecting healthy pediatric brain development as a resource for the scientific community. This third release includes longitudinal imaging and clinical/behavioral data for children ages 7 days to young adult. Included are anatomic MRI and MR spectroscopy data (both raw and processed), along with correlated data from physical neurological examinations, behavioral ratings, neuropsychological testing, structured psychiatric interviews, and hormonal measures from urine and saliva samples. All data has been anonymized to protect the confidentiality of the research participants.

The new data release is available for distribution to qualified researchers in the scientific community with approved applications, consisting of a data access request using standard form 424 (SF424) and a valid Data Use Certification.

Visit or contact to learn more about data access.

The multisite study and resulting repository provide reliable data on a representative sample of healthy, typically-developing children as a basis for elucidating deviations in brain development associated with childhood disorders, as well as access to image processing tools. The study enrolled over 500 children, ranging from infancy to young adulthood, who were evaluated at multiple timepoints, ranging from three timepoints for the older subjects to ten timepoints for some of the youngest subjects. Data collection began in November 2001 and ended in August 2007. Data has been released in stages throughout the course of the study.
Future data release plans include the addition of cortical thickness measures and diffusion tensor imaging (DTI) data (raw and processed) and the connection of this resource with the National Database for Autism Research (, allowing cross data comparisons between these two unique data repositories.

The Pediatric MRI Study of Normal Brain Development was sponsored by four NIH Institutes: the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS). Participating sites included Boston Children's Hospital (Principal Investigator [PI] Michael J. Rivkin), Children's Hospital Medical Center of Cincinnati (PI William S. Ball), Children's Hospital of Philadelphia (PI Dah--Jyuu Wang), Montreal Neurological Institute (PI Alan Evans), University of California at Los Angeles (PI James T. McCracken), University of Texas Health Science Center (PI Michael Brandt), Washington University (PIs Kelly Botteron and Robert McKinstry), and the NICHD—intramural program (PI Carlo Pierpaoli).
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