Posted By: Angie Laird - May 22, 2020
Tool/Resource: NITRC Community
Guest Editors:
Dr. Andrew L Alexander [ ]
Dr. Catherine Lebel [ ]
Dr. Martin Lindquist [ ]

The brain is undergoing constant changes throughout the lifespan, as a function of a wide range of factors including genetics, disease, therapeutics, environment and experience. Longitudinal brain imaging studies may be used to measure and better characterize temporal effects for both individuals and groups, thus providing information that is not available in cross-sectional imaging studies. A wide range of considerations for longitudinal imaging studies include sampling and acquisition design, models, and statistical analysis methods. Ultimately, longitudinal imaging provides an exciting framework to capture and characterize the temporal trajectories of brain structure, microstructure, function, chemistry, electrophysiology and networks as they relate to age, cognition, behavior and pathology.

The goal of this special issue is to interrogate methodological and neuroscientific questions, providing an overview of challenges and opportunities afforded by this emerging perspective. Topics of interest include:

- Novel methods for modeling, analyzing, mapping and visualizing longitudinal brain changes, including tools available to the research community
- Studies demonstrating the utility, strengths and limitations of longitudinal brain imaging
- Techniques and applications for “unmixing” different longitudinal trajectories – e.g., healthy aging from neurodegeneration, separating trajectories in complex and heterogeneous disorders, trajectories that identify patient responders
- Strategies for longitudinal imaging study design including sampling and/or acquisition considerations, harmonization of multi-site and multi-protocol studies
- Large, well-designed longitudinal imaging studies of brain changes

We aim for the majority of articles to be empirical papers, with the remaining devoted to other formats, including opinions, perspectives, and review articles. Pre-submission inquiries are welcome — please contact any of the Guest Editors with questions.

All papers will be subject to peer review and must comply with the Guide for Authors:

To submit a paper to the special issue, please select “VSI: Longitudinal Neuroimaging” as the article type.

Submission portal to be open for papers: April 1, 2020
Submission deadline: August 1, 2020
Acceptance deadline: December 2020

Each article in the special issue is assigned a unique identifier and once the article is accepted will be published in a regular journal issue as soon as available.

The unique identifier allows us to simultaneously add the article to special issue on ScienceDirect which is gradually built up as individual articles are published online.

We do provide Shared Link of the final published version to the corresponding authors with 50 days free access so that they can share it in social media.
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