help > URGENT HELP: Hard time to compare Roi to Roi bewteen 2 or more cohorts. (so far impossible for cluster level correction).
Aug 4, 2026  08:08 AM | Renzo Torrecuso - Max Planck Institute for Human Cognitive and Brain Sciences
URGENT HELP: Hard time to compare Roi to Roi bewteen 2 or more cohorts. (so far impossible for cluster level correction).

Dear Alfonso and CONN users,


I have been strugling for months with what seems to be a limitation of CONN (hopefully is just something I have to learn about the toolbox)


If I compare the Roi to Roi results between 2 diferent cohorts, corrected for cluster level, I run into a strange behaviour of the toolbox: I get VERY different results for even slight changes in the order of the regions in the connectome. Also, if I change the order I get different results that are not at all similar to the previous region order. In other words, you can either not see true results in one cohort or see 2 different results in one cohort. Then, only one of the regions order works in the second cohort. What leaves us with the very dubious task to assume which is "the right" one. 


To make things even more complicated, If you remove the order of the regions, unfortunately thats no garanty that you will get the results in the same order, because even the order of the regions when you "remove the order" changes, is not always shown in a fix order.


Unless there's some procedure which sets some order in the Roi to Roi results, this limitations makes it, unfortunately, unreliable for publication.


Please could anybody help?


Best


Renzo

  Edited (45 minutes ago)