Hello everyone,

I have a question regarding the NBS-Toolbox. We collected MRI data from patients at two time points and now want to run two 2x2 repeated measure ANOVAs, with the two time points (pre and post; binary), therapy response (responder, non-responder, binary) and neuroticism (only pre; metric) as factors. For the first hypothesis we want to investigate whether changes in the connectome are associated with therapy response.

I have attached the DesignMatrix, contrasts and exchange blocks below, just to make sure we coded everything correctly.

For the second hypothesis we wanted to see whether changes in the connectome are associated with neuroticism, which we only measured at the first time point (since it’s a stable variable). We were wondering how you’re supposed to code the Design-Matrix for that. Should we put 0s in for the second timepoint and calculate the interaction that way? Or should we put the same values for Neuroticism in both time points? Is there a difference in desgin between binary and metric variables? The second sheet includes an option for the second hypothesis, maybe someone knows the correct coding.

I would really appreciate the help!

Eva