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help > RE: Regarding group-level matrix thresholding
Aug 6, 2015 11:08 AM | Andrew Zalesky
RE: Regarding group-level matrix thresholding
Hi,
I certainly don't think that the "one group" option is necessarily incorrect.
Which option is most appropriate depends on the hypothesis you are testing.
For example, if the alternative hypothesis is a reduction in connectivity in group X relative to group Y, then thresholding based on a one-sample t-test in group Y alone (the controls) might be justifiable. Thresholding based on groups X and Y combined can potentially exclude too many connections from subsequent testing, resulting in false negatives.
Andrew
Originally posted by :
I certainly don't think that the "one group" option is necessarily incorrect.
Which option is most appropriate depends on the hypothesis you are testing.
For example, if the alternative hypothesis is a reduction in connectivity in group X relative to group Y, then thresholding based on a one-sample t-test in group Y alone (the controls) might be justifiable. Thresholding based on groups X and Y combined can potentially exclude too many connections from subsequent testing, resulting in false negatives.
Andrew
Originally posted by :
Hi Andrew,
I appreciate your very quick response.
I believe I follow, but I want to be certain that I do:
So, say we are interested in identifying group-level abnormalities associated with a diseased group as compared to a healthy group. It would be incorrect to include only connections that are different from zero in both groups *or* one group, and correct to include only connections that are different from zero across all individuals (diseased and healthy), right?
I've seen published papers in my subfield that have included connections based on only *one* group's values differing from zero, which it sounds like is incorrect, right?
Do you have a citation for a paper that properly does this in an NBS study of effects associated with a particular group? It would be helpful to look over a paper that has done it correctly.
Thank you!
I appreciate your very quick response.
I believe I follow, but I want to be certain that I do:
So, say we are interested in identifying group-level abnormalities associated with a diseased group as compared to a healthy group. It would be incorrect to include only connections that are different from zero in both groups *or* one group, and correct to include only connections that are different from zero across all individuals (diseased and healthy), right?
I've seen published papers in my subfield that have included connections based on only *one* group's values differing from zero, which it sounds like is incorrect, right?
Do you have a citation for a paper that properly does this in an NBS study of effects associated with a particular group? It would be helpful to look over a paper that has done it correctly.
Thank you!
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| Title | Author | Date |
|---|---|---|
| Aug 6, 2015 | ||
| Andrew Zalesky | Aug 6, 2015 | |
| Aug 6, 2015 | ||
| Andrew Zalesky | Aug 6, 2015 | |
| Alfonso Nieto-Castanon | Aug 6, 2015 | |
| Andrew Zalesky | Aug 9, 2015 | |
| Aug 10, 2015 | ||
| Andrew Zalesky | Aug 10, 2015 | |
| Corinna Bauer | Mar 23, 2016 | |
| Andrew Zalesky | Mar 24, 2016 | |
| Aug 6, 2015 | ||