help > RE: need help with dynamic FC between conditions
Apr 25, 2016  07:04 PM | Alfonso Nieto-Castanon - Boston University
RE: need help with dynamic FC between conditions
Hi Shukti and Stephen,

Regarding DynamicFC analyses in the context of multiple conditions, you should simply create one additional condition (e.g. named 'rest') encompassing all of your sessions/conditions, and then select that condition in the 'rest condition' field in the FirstLevel.DynamicFC tab. This will use your entire dataset (both conditions in your case) for the dynamic FC analyses. Then, when clicking 'Done', if you want to obtain condition-specific measures (e.g. look at the components separately between your two conditions) simply check the 'All conditions' checkbox in that gui before clicking on 'Start'.

Regarding DynamicFC analyses in the context of multiple groups (e.g.controls vs. patients) that is perfectly fine. We are hoping to have a manuscript out shortly detailing the specificities of these analyses, but both conceptually and in practice the way these analyses work is very similar to ICA analyses. You first estimate a number of dynamic components using your entire dataset (all subjects across multiple subject groups) and then those global components are "backprojected" into subject-specific and condition-specific factors, allowing you to then compare how these components are expressed across different conditions or across different subject groups. Compared to simply running the analyses separately across different subject groups, which would then require users to manually identify the potentially-similar components across the different analysis results, this methodology allows you to more meaningfully and automatically identify individual components across all subjects, while still allowing to investigate how these individual components might be expressed differently across different subjects or conditions. 

Hope this helps
Alfonso
 
Originally posted by Stephen L.:
I am no expert in CONN, but I had the same issue just now. In my case, I just converted the two conditions into two sessions for each subject, and then the Dynamic FC could be computed correctly. I think it should also be perfectly acceptable for your case since rest1 and rest2 are really just two sessions for the same subjects, so you don't need to put them as different conditions.

However, I have another study where there are really two different conditions (controls vs patients), and in this case, if as you say CONN cannot yet find the connectivity for independent conditions, then CONN cannot yet be used for this kind of study. If someone has a solution to this issue, that would be great...

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TitleAuthorDate
Shukti Ramkiran Apr 22, 2016
Stephen L. Apr 22, 2016
RE: need help with dynamic FC between conditions
Alfonso Nieto-Castanon Apr 25, 2016
Stephen L. Apr 26, 2016
Alfonso Nieto-Castanon Apr 26, 2016
Stephen L. May 26, 2016
Shukti Ramkiran Apr 26, 2016