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help > Correlating behavioral measures with functional networks
Dec 16, 2019 08:12 PM | avantika mathur - UNL
Correlating behavioral measures with functional networks
Dear CONN users,
I have analyzed 24 subject data for executive functioning task in CONN. The task contains three conditions GNG (go nogo block), Go (Go block) and rest block. I want to understand:
(1) Executive function network for the contrast GNG>GO.
To understand the executive function network, I use the contrast for subject effects, ALL subjects, IQ, as 1 0, and the condition contrast for conditions GNG and GO as [1 -1].
(2) How the connectivity of the executive network (for the contrast GNG>Go) varies with the score of participants for some reading measures while controlling for IQ.
So, in order do so, I am setting the between subjects contrast for subject effects, ALL subjects, IQ, Reading score as 0 0 1, and the condition contrast for conditions GNG and GO as [1 -1].
When I do so, I do observe connections at FDR corrected threshold 0.05 that vary with reading score (for eg., R STG - R SPL), that actually does not appear in the Executive function network for the contrast GNG>GO at FDR corrected threshold 0.05.
My questions are:
1. Am I setting the contrasts right?
How do I explain the results am I am observing? If a connection is not surviving in the network for executive function for the contrast GNG>GO, how can the connection strength of the same vary with the reading score?
2. I only want to analyze the modulation of the connections that survive the FDR corrected threshold of 0.05 (for Executive function network for the contrast GNG>GO) with reading ability. How do I do that?
Thanks in advance,
Avantika
I have analyzed 24 subject data for executive functioning task in CONN. The task contains three conditions GNG (go nogo block), Go (Go block) and rest block. I want to understand:
(1) Executive function network for the contrast GNG>GO.
To understand the executive function network, I use the contrast for subject effects, ALL subjects, IQ, as 1 0, and the condition contrast for conditions GNG and GO as [1 -1].
(2) How the connectivity of the executive network (for the contrast GNG>Go) varies with the score of participants for some reading measures while controlling for IQ.
So, in order do so, I am setting the between subjects contrast for subject effects, ALL subjects, IQ, Reading score as 0 0 1, and the condition contrast for conditions GNG and GO as [1 -1].
When I do so, I do observe connections at FDR corrected threshold 0.05 that vary with reading score (for eg., R STG - R SPL), that actually does not appear in the Executive function network for the contrast GNG>GO at FDR corrected threshold 0.05.
My questions are:
1. Am I setting the contrasts right?
How do I explain the results am I am observing? If a connection is not surviving in the network for executive function for the contrast GNG>GO, how can the connection strength of the same vary with the reading score?
2. I only want to analyze the modulation of the connections that survive the FDR corrected threshold of 0.05 (for Executive function network for the contrast GNG>GO) with reading ability. How do I do that?
Thanks in advance,
Avantika
