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help > How to consider effects of baseline resting-state in ANOVA anaylsis
Nov 5, 2020 06:11 AM | jun Kim - Korea University Guro hospital
How to consider effects of baseline resting-state in ANOVA anaylsis
Dear conn users and Dear Alfonso
I have a question about my design setup.
I have 2 groups (individuals who underwent different interventions, Ma and Mb), and each group underwent cognitive tasks before and after the intervention. Two resting-state fMRI was acquired after cognitive tasks.
So, my study design comprises of 5 conditions (baseline resting-state, cognitive task2 [C1], resting-state[P1], intervention[M], cognitive task2 [C2], resting-state[P2]).
I want to test the hypothesis that different interventions (Ma vs. Mb) may differently alter functional connectivity during cognitive tasks (C1 vs. C2) and resting-state FC after cognitive tasks (P1 vs. P2).
For this, I did two 2x2 ANOVA anaylses.
ANOVA1: interaction between groups (Ma and Mb) and conditions (resting state after cognitive tasks, P1 and P2)
Between-subject contrast: [-1 1]
Between-condition contrast: [-1 1]
ANOVA2: interaction between groups (Ma and Mb) and conditions (during cognitive tasks, C1 and C2)
Between-subject contrast: [-1 1]
Between-condition contrast: [-1 1]
My first question is whether I should include baseline resting-state in between-condition contrast and how to include.
In my opinion, I would be able to include baseline condition by addressing baseline condition as a covariate as;
Between-condition contrast (B, P1, P2): [0 -1 1]
or, subtracting baseline condition from other condition conditions as;
Between-condition contrast (P1-B, P2-B): [-1 1]
Suppose I would be better to include the baseline condition, which of the two ways is more appropriate. Or is there any other better way?
Additionally, I also ask how to make a second analysis, "Between-condition contrast (P1-B, P2-B): [-1 1]".
Best
Jun
I have a question about my design setup.
I have 2 groups (individuals who underwent different interventions, Ma and Mb), and each group underwent cognitive tasks before and after the intervention. Two resting-state fMRI was acquired after cognitive tasks.
So, my study design comprises of 5 conditions (baseline resting-state, cognitive task2 [C1], resting-state[P1], intervention[M], cognitive task2 [C2], resting-state[P2]).
I want to test the hypothesis that different interventions (Ma vs. Mb) may differently alter functional connectivity during cognitive tasks (C1 vs. C2) and resting-state FC after cognitive tasks (P1 vs. P2).
For this, I did two 2x2 ANOVA anaylses.
ANOVA1: interaction between groups (Ma and Mb) and conditions (resting state after cognitive tasks, P1 and P2)
Between-subject contrast: [-1 1]
Between-condition contrast: [-1 1]
ANOVA2: interaction between groups (Ma and Mb) and conditions (during cognitive tasks, C1 and C2)
Between-subject contrast: [-1 1]
Between-condition contrast: [-1 1]
My first question is whether I should include baseline resting-state in between-condition contrast and how to include.
In my opinion, I would be able to include baseline condition by addressing baseline condition as a covariate as;
Between-condition contrast (B, P1, P2): [0 -1 1]
or, subtracting baseline condition from other condition conditions as;
Between-condition contrast (P1-B, P2-B): [-1 1]
Suppose I would be better to include the baseline condition, which of the two ways is more appropriate. Or is there any other better way?
Additionally, I also ask how to make a second analysis, "Between-condition contrast (P1-B, P2-B): [-1 1]".
Best
Jun
Threaded View
| Title | Author | Date |
|---|---|---|
| jun Kim | Nov 5, 2020 | |
| Alfonso Nieto-Castanon | Nov 10, 2020 | |
| jun Kim | Nov 11, 2020 | |
