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help > RE: Multisite data harmonisation and CONN
Oct 10, 2021 12:10 AM | Alfonso Nieto-Castanon - Boston University
RE: Multisite data harmonisation and CONN
Hi Yann,
This is a very interesting suggestion. As far as I know each individual analysis would require a separately harmonisation, e.g. you could harmonise the first-level SBC maps across sites to then perform 2nd-level analyses of SBC maps, or you could harmonise the first-level RRC matrices across sites to then perform 2nd-level analyses of RRC matrices, but I have not seen (yet?) any method that would allow you harmonise the original BOLD signal data or other intermediate sources so that all subsequent connectivity measures derived from these are then automatically balanced across sites (but would love to hear about such approaches). In the absence of that, the simplest / first-order approach that I often recommend is to simply include site as control covariates directly in your second-level analyses (e.g. https://www.nitrc.org/forum/message.php?...), which can of course be equally used in the analysis of any arbitrary connectivity measure
Hope this helps
Alfonso
Originally posted by Yann Quide:
This is a very interesting suggestion. As far as I know each individual analysis would require a separately harmonisation, e.g. you could harmonise the first-level SBC maps across sites to then perform 2nd-level analyses of SBC maps, or you could harmonise the first-level RRC matrices across sites to then perform 2nd-level analyses of RRC matrices, but I have not seen (yet?) any method that would allow you harmonise the original BOLD signal data or other intermediate sources so that all subsequent connectivity measures derived from these are then automatically balanced across sites (but would love to hear about such approaches). In the absence of that, the simplest / first-order approach that I often recommend is to simply include site as control covariates directly in your second-level analyses (e.g. https://www.nitrc.org/forum/message.php?...), which can of course be equally used in the analysis of any arbitrary connectivity measure
Hope this helps
Alfonso
Originally posted by Yann Quide:
Hi Alfonso,
I am working with multisite data and was wondering what would be the best option when to include the scanner site harmonisation step (using the neuroHarmonize tools)? It is usually recommended to harmonise the first level files, but this will not include correlation matrices.
What file(s) would you recommend to be harmonised that will allow any type of subsequent analysis (ROI to ROI, seed based, etc)?
Thanks in advance,
Yann
I am working with multisite data and was wondering what would be the best option when to include the scanner site harmonisation step (using the neuroHarmonize tools)? It is usually recommended to harmonise the first level files, but this will not include correlation matrices.
What file(s) would you recommend to be harmonised that will allow any type of subsequent analysis (ROI to ROI, seed based, etc)?
Thanks in advance,
Yann
Threaded View
| Title | Author | Date |
|---|---|---|
| Yann Quide | Oct 6, 2021 | |
| Alfonso Nieto-Castanon | Oct 10, 2021 | |
| Yann Quide | Oct 10, 2021 | |
| Yann Quide | Oct 14, 2021 | |
| Alfonso Nieto-Castanon | Oct 14, 2021 | |
| Yann Quide | Oct 18, 2021 | |
| Alfonso Nieto-Castanon | Oct 18, 2021 | |
| Yann Quide | Oct 9, 2021 | |