Hello Intelligence out there,

wie have the following baseline data

Groups:

154 Panic patients
95 Social phobia patients
190 specific phobia patients
105 healthy controls

We wan't to test for transdiagnostic commonalities and differences.

A first analysis was just to compare the different patient groups to healthy controls ROI-to-ROI with defensive network ROIs and some more. we found different differences and especialy man differences in the panic group.

I am about to write a paper on that and report the comparisons between patient groups in the supplement only, as i think it is difficult to interpret more than our first very basic analysis. dimensional measures (HAM-A, CGI, PAS, LSAS) didn't bring any significance...

how would you test for commonalities? what do you think about our approach? in our field it is more common to test against HCs than to compare directly, when testing for transdiagnostic assumptions...

I hope this is an interesting discussion for you!

greetings from Berlin

Till