Dear CONN users,

I'm working with 51 user-defined ROIs in CONN, doing an ROI-to-ROI analysis only, with a 2nd level analysis using the 'standard settings for cluster-based inferences #1: Functional Network Connectivity' option.

For this FNC option, there is the second setting for 'cluster-level p-FDR corrected (MVPA omnibus test)'.

Exactly  how is MVPA (omnibus test) used for this ROI-to-ROI FNC? Is it the same SVD-based mathematical formulation as voxel-to-voxel fc-MVPA, or a different algorithm?

Also, is 51 ROIs a large enough sample to use cluster-level methods for mult comparison correction?  It might be that 51 ROIS (1275 pairs of connections) is too few for a proper cluster-level correction method. 

Thanks for your help,

Chris