help > RE: How to interpret CONN's RRC charts?
Oct 15, 2023  09:10 PM | Alfonso Nieto-Castanon - Boston University
RE: How to interpret CONN's RRC charts?

Dear Renzo


In RRC ROI-level statistics a separate statistic is computed for each individual ROI, evaluating the strength of the results among all connections between that ROI and the rest of the brain (or more precisely the rest of the ROIs in your analysis). This is done for every individual seed-ROI and after that those ROI-level statistics are corrected for multiple comparisons (across all seed-ROIs using FDR) and only those seed-ROIs that survive your p-FDR<.05 threshold are shown. In your case it appears that the only significant ROI that survives this threshold is that cerebellar area, and the connections displayed in those results simply summarize what are the strongest connections between this area and the rest of the brain that produced that result (so for example, if you original analysis was a comparison of connectivity between two groups, then these results would indicate that the connectivity pattern between Cereb45 and the rest of the brain differs between the two groups in a relatively widespread manner, and you would then look to use 'plot effects' to characterize a bit more how precisely those connections with Cereb45 are different in the two groups)


Hope this helps


Alfonso


 


Originally posted by Renzo Torrecuso:



Dear Alfonso or CONN expert,


Please find attached a ROI-level 0.05 FWE correct RRC plot.


Could you please clarify what does this image mean? The Vermis and Cerebellum seem to be the "origin", some kind of hub from which all connections leave to all other regions. What does it mean and why does this happen if I selected all regions in the RRC analysis?


Thanks a lot


All best


Renzo



 

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TitleAuthorDate
Renzo Torrecuso Oct 6, 2023
RE: How to interpret CONN's RRC charts?
Alfonso Nieto-Castanon Oct 15, 2023