Dear Samim

Comparing a single subject to another cohort is perfectly fine. You may do that within CONN using the standard GLM second-level analysis tools available. In the context of GLM a between-group comparison where one of the groups has only one subject is mathenatically exactly equivalent to your planned Crawford-Howell t-test, so you could run those analyses simply from the second-level results tab selecting the reference group and another group identifying a single subject and entering a [-1 1] between-subjects contrast. 

Hope this helps

Alfonso

Originally posted by Mohammad Samim Zaheer:

Dear Alfonso,

 

Thank you for your detailed clarification. I understand that comparing a single subject to another cohort is not supported. However, if I want to export connectivity data for a specific ROI, such as the IFG, to perform a Crawford-Howell t-test outside of CONN, what steps should I follow?

 

Is it possible to obtain this data? If so, could you advise on the appropriate extraction method and recommend which type of analysis I should use?

 

For context, I have data from 10 GBM patients and 15 controls. I would like to compare each patient individually to the control group before conducting a group analysis.

 

Thanks again for your help!

Samim