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help > RE: Design setup for multi-session experiment
Jan 27, 2017 01:01 AM | Alfonso Nieto-Castanon - Boston University
RE: Design setup for multi-session experiment
Hi Nicole,
If I am understanding correctly you would set this up simply by entering 6 as the number of runs per subject (six runs, with 341 volumes each), entering the corresponding functional data (6 sessions/runs per subject), and then defining 18 conditions in a 3 (rest,0-back,2-back) by 3 (pre-, during-, post- stimulation) by 2 (active vs. sham) design. CONN will then compute connectivity for each of your conditions (individual cells in your 3x3x2 design), and then you can simply define your desired contrasts of interest in the second-level results tab (e.g. assuming that you are ordering your 18 conditions as active_pre_rest, active_pre_0back, .... , sham_post_0back, sham_post_2back, then a [0 1 -1 0 -1 1 0 0 0 0 0 0 0 0 0 0 0 0] contrast would evaluate the 2back-0back difference during stimulations compared to the same 2back-0back difference prior to stimulation, both in the 'active' condition)
Hope this helps
Alfonso
Originally posted by Nicole Nissim:
If I am understanding correctly you would set this up simply by entering 6 as the number of runs per subject (six runs, with 341 volumes each), entering the corresponding functional data (6 sessions/runs per subject), and then defining 18 conditions in a 3 (rest,0-back,2-back) by 3 (pre-, during-, post- stimulation) by 2 (active vs. sham) design. CONN will then compute connectivity for each of your conditions (individual cells in your 3x3x2 design), and then you can simply define your desired contrasts of interest in the second-level results tab (e.g. assuming that you are ordering your 18 conditions as active_pre_rest, active_pre_0back, .... , sham_post_0back, sham_post_2back, then a [0 1 -1 0 -1 1 0 0 0 0 0 0 0 0 0 0 0 0] contrast would evaluate the 2back-0back difference during stimulations compared to the same 2back-0back difference prior to stimulation, both in the 'active' condition)
Hope this helps
Alfonso
Originally posted by Nicole Nissim:
Hello CONN users,
I have data from 16 subjects who ran through three in scanner tasks that I would like to treat independently (341 volumes each): the task in scanner was three runs of N-Back task containing 0-back, 2-back, and rest conditions within the task. For the 3 sessions, first was baseline N-Back, second they received brain stimulation during N-Back, and third is post-stimulation N-back. I want to examine ROI-to-ROI connectivity at the second level by comparing the second session (N-Back during active stimulation) looking at 2-Back over 0-Back with the first session (baseline N-Back, 2-back over 0-back) and the third session (post-stimulation N-Back, 2- over 0-back). Is there a way to do this in CONN without having to process the 3 sessions in different experiments, as if the data were acquired from different subjects?
Additionally, this was a within-group design, and I have 3 sessions of data for the same subjects that were acquired at a separate visit. They only difference is they received sham instead of active stimulation during the second N-Back run. Would I be able to run the 6 sessions in one experiment to examine ROI-to-ROI connectivity differences in the sham stimulation N-Back run with the active stimulation run?
Any help on how the best way to set up the experiment in CONN would be greatly appreciated.
Best regards,
Nicole
I have data from 16 subjects who ran through three in scanner tasks that I would like to treat independently (341 volumes each): the task in scanner was three runs of N-Back task containing 0-back, 2-back, and rest conditions within the task. For the 3 sessions, first was baseline N-Back, second they received brain stimulation during N-Back, and third is post-stimulation N-back. I want to examine ROI-to-ROI connectivity at the second level by comparing the second session (N-Back during active stimulation) looking at 2-Back over 0-Back with the first session (baseline N-Back, 2-back over 0-back) and the third session (post-stimulation N-Back, 2- over 0-back). Is there a way to do this in CONN without having to process the 3 sessions in different experiments, as if the data were acquired from different subjects?
Additionally, this was a within-group design, and I have 3 sessions of data for the same subjects that were acquired at a separate visit. They only difference is they received sham instead of active stimulation during the second N-Back run. Would I be able to run the 6 sessions in one experiment to examine ROI-to-ROI connectivity differences in the sham stimulation N-Back run with the active stimulation run?
Any help on how the best way to set up the experiment in CONN would be greatly appreciated.
Best regards,
Nicole
Threaded View
| Title | Author | Date |
|---|---|---|
| Nicole Nissim | Jan 26, 2017 | |
| Alfonso Nieto-Castanon | Jan 27, 2017 | |
| Nicole Nissim | Jun 21, 2017 | |
| Nicole Nissim | Feb 10, 2017 | |
| Alfonso Nieto-Castanon | Feb 11, 2017 | |