Dear Dr. Nieto-Castanon,
 
Thank you for the CONN toolbox. I'm performing resting-state functional connectivity projects. I've downloaded the latest version of the CONN (v.13n) and found new options including 'RegBP or Simult', detrending, and despiking. Everything in the latest updates to the CONN is excellent. You recommend a procedure referred as 'Simult' (simultaneous regression and band-pass). How about detrending and despiking?
 
Q1) Some researchers have performed only one nuisance signal regression procedure including motion parameters, CompCorr signals, and linear trend for each subject's rs-fMRI data. How about the CONN toolbox? Is the CONN (v.13n) performed nuisance regression procedure including motion parameters and CompCorr singals (or with band-pass filtering as 'Simult' option) and linear detrending separately or all together? 
 
Q2) Could you tell me the order in which the following procedures are processed in the CONN toolbox ?
- (i) nuisance regression, (ii) band-pass filtering, (iii) detredning, and (iv) despiking. 
 
Q3) As I known, researchers conducted despiking before slice timing correction. Is there any problem to perform despiking on preprocessed data (i.e., slice timing, realigned, normalized, and smoothed data)?
 
Thank you