Hello,

On the CONN website, it indicates that GSR can be completed by "simply defining a new ROI encompassing the entire brain (e.g. a subject-specific brain mask resulting from the outlier detection step during preprocessing, or gray matter mask resulting from the segmentation step) and using this ROI as an additional potential confounding effect in the standard Linear Regression denoising step."

If I include a subject-specific grey-matter mask in the Confounds section of the denoising step, should I still include the WM and CSF ROIs as Confounds? Or would the combination of CompCor + GSR become an issue?

Thank you,
Ben